The CDC is reporting a nationwide increase in human exposures to rabid or potentially rabid animals since July 2026, along with an increase in errors involving rabies post-exposure prophylaxis (PEP). The CDC is reminding clinicians and healthcare facilities to conduct careful rabies risk assessments before administering PEP and to follow ACIP recommendations for the proper administration of human rabies immune globulin (HRIG) and rabies vaccines when treatment is indicated.