A new report in the Morbidity and Mortality Weekly Report from the Centers for Disease Control and Prevention highlights a sharp increase in infections linked to Kaposi Sarcoma–associated herpesvirus (KSHV) among U.S. solid organ transplant recipients between 2021 and 2025. During this period, 46 donors were suspected of transmitting the virus—up significantly from previous years—leading to infections in nearly half of the 153 recipients who received organs from those donors, including 25 deaths. Because transplant recipients take immunosuppressive medications that increase vulnerability to severe complications such as Kaposi sarcoma and related disorders, clinicians are encouraged to remain vigilant, consider testing when risk factors are present, and report suspected donor-derived infections to the transplant network.